A new non-hormonal medication, elinzanetant (marketed as Lynkuet), received FDA approval in October, offering a fresh option for women struggling with hot flashes. Experts emphasize that while effective treatments exist, many women suffer unnecessarily, and persistent hot flashes may pose health risks beyond discomfort.
The Problem: Hot Flashes and Their Impact
Hot flashes affect up to 80% of women experiencing menopause, causing sudden intense heat, sweating, and sleep disruption. These symptoms can significantly impact quality of life, and recent research links them to increased risks of cardiovascular disease, osteoporosis, and cognitive decline. Ignoring hot flashes isn’t just about comfort; it may contribute to long-term health problems.
Elinzanetant: How It Works and Who It’s For
Elinzanetant targets the brain’s temperature regulation system, specifically the hypothalamus, which becomes overactive during menopause due to declining estrogen levels. The drug blocks this hyperactivity, reducing both hot flashes and related sleep disturbances. Trials show it works within a week and is effective regardless of whether menopause is natural or surgically induced (after ovary removal). Crucially, it’s proven safe for women with breast cancer, who often cannot take hormone therapy.
Hormone Therapy Remains Gold Standard, But Not For Everyone
While elinzanetant is a valuable addition, experts still consider hormone therapy the most effective treatment for hot flashes – if a woman is a suitable candidate. Guidelines recommend hormone therapy for women under 60 or within 10 years of menopause onset, due to its additional benefits like preventing bone loss and improving vaginal health. However, hormone therapy isn’t risk-free and is contraindicated for some individuals.
Common Myths Debunked
Many misconceptions surround hot flashes. They often start before menopause fully sets in (during perimenopause), and they can last for years – even a decade or more, particularly for Hispanic and African American women. Over-the-counter remedies have limited proven effectiveness, offering little beyond a placebo response. While hypnosis and cognitive behavioral therapy may provide some relief, they aren’t cures.
Finally, hot flashes aren’t just a nuisance; they’re linked to serious health risks. While elinzanetant won’t treat bone loss directly, the association between hot flashes and cardiovascular/cognitive health is an active area of research.
The Bottom Line: Talk to Your Doctor
If you experience bothersome hot flashes, seeking professional guidance is essential. A healthcare provider can assess your individual risk factors, discuss treatment options (including hormone therapy and elinzanetant), and help you make the best decision for your health. Ignoring these symptoms could mean missing out on effective relief and potentially increasing your long-term health risks
